Gut Hormone, Nociceptors, Neurotrophic Factors Expression in Functional Dyspepsia

Ghrelin, Leptin, Serotonin, TRPV1, NGF and GDNF Expression in the Patients With Functional Dyspepsia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02173925

Acronym

Enrollment

314

Registered

2014-06-25

Start date

2011-02-28

Completion date

2014-12-31

Last updated

2015-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Functional Dyspepsia, H. Pylori Infection

Brief summary

The pathophysiology of functional dyspepsia is still unclear but several peptides have been indicated in the etiological factors in FD. Ghrelin and leptin are involved in regulation of appetite and gut motility and serotonin is a typical neurotransmitter related with sensory and motor functions of gut. On the other hand, transient receptor potential vanilloid receptor 1 (TRPV1) has been proposed to be involved with functional gastrointestinal disorder, and expression of this receptor could be regulated by nerve growth factor (NGF) or glial cell-line derived neurotrophic factor (GDNF). The investigators aimed to determine whether expressions of ghrelin,leptin, serotonin,TRPV1,GDNF and NGF in blood or gastric mucosa of FD patients are different from those in healthy controls, and whether some changes of their expression correlate with certain dyspeptic symptoms. The investigators also investigated the effect of H. pylori infection by comparing their expressions before and one year after H. pylori eradication.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Subjects who completed upper GI endoscopy and questionnaire about gastrointestinal symptoms

Exclusion criteria

* Daily user of NSAID or anticoagulants * with concomitant systemic diseases such as diabetes mellitus or any malignancy * Participants with major depression, psychosis, eating disorder * Participants with typical reflux symptom * Patients with Benign gastric ulcer or duodenal ulcer * Patients with past gastrointestinal surgery

Design outcomes

Primary

Measure	Time frame
Level of fasting plasma acyl ghrelin	Baseline

Secondary

Measure	Time frame
Change of gastric mRNA ghrelin, leptin, TRPV1, NGF and GDNF expression and blood level of acyl ghrelin, leptin and serotonin	Baseline/ 1year
Expression of gastric ghrelin, leptin, TRPV1, NGF and GDNF mRNA and blood level of des-acyl ghrelin and serotonin	Baseline

Countries

South Korea

Outcome results