Reduction the Duration of Antibiotic Therapy in the Elderly (PROPAGE)

Reduction of the Duration of Antibiotic Guided by Procalcitonin in Infections Lungs of Hospitalized Elderly: a Randomized

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02173613

Acronym

PROPAGE

Enrollment

117

Registered

2014-06-25

Start date

2012-08-31

Completion date

2016-03-31

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Infection

Keywords

infection lung elderly patients

Brief summary

The main objective is to evaluate the interest of the repeated measurement of procalcitonin in patients with pulmonary infection to reduce the duration of antibiotic therapy in comparison with a conventional clinical strategy.

Interventions

OTHERprocalcitonine

The recommendations will be based on the level of PCT: 4 levels of advice will be given: * It is highly recommended to stop antibiotics if PCT \<0.1ng/ml, and the recommended stop if 0.1ng/ml \<PCT \<0.25 ng / ml. * It is recommended to continue treatment if 0.25 ng / ml \<PCT ng / ml. * Finally, if the initial PCT greater than 10 ng / ml, a stop will be advised in case of reduction to less than 10% of baseline level.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

80 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 80 years * Started antibiotics for a chest infection * Procalcitonin performed J0 antibiotic treatment * Person affiliated to the social security

Exclusion criteria

* Patients with a documented infection with germs after Listeria spp, Legionella pneumophilia, Mycobacterium tuberculosis * Patients with a documented infection with a virus or parasite (eg hemorrhagic fever, malaria) * Patients with endovascular infection associated (endocarditis, pacemaker. Intravascular catheter) * Patients with lung abscess associated upon entry Patients with a chronic infection associated * Patients with severe immunosuppression (HIV or transplant) * Palliative patient * Death within 24 hours of admission to nursing units. * Presence of antibiotic treatment for chronic infection. * Patient under guardianship, curatorship or any other administrative or judicial action or deprivation of the right or freedom * Patients hospitalized without their consent

Design outcomes

Primary

Measure	Time frame
Duration of antibiotic therapy	Success of antibiotic therapy within 45 days of inclusion

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026