Spinal Injury
Conditions
Brief summary
Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology. In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.
Interventions
None listed
Sponsors
Foundation Wings For Life
Balgrist Foundation
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Cervical injury * Informed consent * Age 18-80 * CSM
Exclusion criteria
* No other neurologic disorder and psychiatric disorder * Seizure * MRI incompatibility * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphometric changes and changes in cerebro spinal fluid (CSF) flow and spinal cord movement in patients and control subjects will be correlated to functional deficits and neurophysiological data (regression model analysis). | Each patient will undergo a MRI scan, clinical and electrophysiological examinations at baseline, after 6 months and after 1, 2, 3, 4, and 5 years. Controls will undergo 1 MRI scan and some scan of retest analysis |
| Assessment of CSF pressure dynamics in the perioperative setting | Perioperative for 24hours |
Countries
Switzerland
Contacts
Primary ContactPatrick Freund, PhD
Outcome results
None listed