Liver Neoplasms
Conditions
Keywords
hepatic ischemia reperfusion injury, ischemia precondition, remote ischemia precondition, anti-inflammation
Brief summary
Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.
Detailed description
Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.
Interventions
OTHERRemote ischemia precondition
Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff placed on the right upper arm served as RIPC stimulus.
OTHERNone remote ischemia precondition
Placed an uninflated cuff on the right upper arm for 30 min.
Sponsors
Eastern Hepatobiliary Surgery Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade * Selective hepatectomy, one time hepatic portal occlusion * Child-Pugh A
Exclusion criteria
* Peripheral vessels diseases * Not the same surgical procedure as expected * Administered anti-inflammatory drugs as glucocorticoid etc * Diagnosed of diabetes * History of liver surgery * History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy * Refuse to join the research * Patients with psychopathy * Acute infection need antibiotic therapy * Hepatic artery or portal vein embolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival rate | 30 days postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| alanine aminotransferase (ALT) level in patients' blood | 1 day postoperatively | Examine the patients's blood sample for ALT level at 1 day postoperatively |
| aspartic transaminase (AST) level in patients' blood | 1 day postoperatively | Examine the patients's blood sample for AST level at 1 day postoperatively |
| complications | 30 days postoperatively | Number of participants with adverse events within 30 days postoperatively |
Countries
China
Contacts
Primary ContactWeifeng Yu, professor
Outcome results
None listed