Psychotic Disorders
Conditions
Keywords
Neurological Disorders, Neuroscience, Neuropsychology, EEG, Cognitive remediation, Cognitive Response
Brief summary
Cognitive remediation (CR) therapies refer to a number of recent developments to use behavioural strategies to improve neurocognitive abilities and improve everyday functioning in mental disorders such as schizophrenia, bipolar disorder, and depression. In this study, we aim to examine whether we can observe CR effects on measures of neuroplasticity, cognition, and functioning when using a rigorous control comparison group. We hypothesize that the active group will exhibit improvements in executive functioning composite scores, improved EEG theta-gamma frequency modulation, and increased EEG alpha power compared to the placebo group.
Interventions
BEHAVIORALExecutive Function Training
BEHAVIORALPlacebo
Placebo version of executive function training
Sponsors
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of a chronic mental disorder (defined herein as bipolar disorder, major depressive disorder, or a schizophrenia-spectrum disorder) * between the ages of 18 and 65 * speak and read fluent English * able to use a computer
Exclusion criteria
* active substance abuse or dependence diagnosis * sensory or motor issues that would preclude completion of study procedures * enrollment in a cognitive remediation program or use of cognitive training programs (e.g. lumosity.com) within the past 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline executive functioning composite score at post-treatment assessment | Pre-training assessment (Week 1) and post-training assessment (Week 4) | Composite score based on four tests of cognition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline EEG theta-gamma frequency modulation at post-treatment assessment | Pre-training assessment (Week 1) and post-training assessment (Week 4) | Predicted to improve in active CR (cognitive remediation) condition compared to placebo CR |
| Change from baseline EEG alpha power at post-treatment assessment | Pre-training assessment (Week 1) and post-training assessment (Week 4) | Predicted to increase in active CR (cognitive remediation) condition compared to placebo CR |
Countries
Canada
Outcome results
None listed