Brain Stimulation for Traumatic Brain Injury

Conditions

Diffuse Axonal Injury, Traumatic Brain Injury

Keywords

traumatic brain injury, diffuse axonal injury, repetitive transcranial magnetic stimulation, neuromodulation, cognitive rehabilitation

Brief summary

The purpose of this study is to determine whether repetitive Transcranial Magnetic Stimulation (rTMS) is effective in the cognitive rehabilitation of patients with diffuse axonal injury(DAI) after Traumatic Brain Injury(TBI).

Priscila Aparecida Rodrigues, Ana Luiza Zaninotto, Hayden M. Ventresca, Iuri Santana Neville, Cintya Yukie Hayashi et al. (9 authors)

Frontiers in Neurology2020-12-049 citations

10.3389/fneur.2020.564940

Repetitive TMS does not improve cognition in patients with TBI: A randomized double-blind trial.

Neville IS, Zaninotto AL, Hayashi CY, Rodrigues PA, Galhardoni R, Ciampi de Andrade D, Brunoni AR, Amorim RLO, Teixeira MJ, Paiva WS.

2019-06-0733 citations

10.1212/wnl.0000000000007748

Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial.

Neville IS, Hayashi CY, El Hajj SA, Zaninotto AL, Sabino JP, Sousa LM, Nagumo MM, Brunoni AR, Shieh BD, Amorim RL, Teixeira MJ, Paiva WS.

2015-10-0523 citations

10.1186/s13063-015-0944-2

Interventions

OTHERActive Coil

The patients will undergo 10 sessions (2,000 pulses each, lasting 20 minutes) of repetitive transcranial magnetic stimulation over the left dorsolateral prefrontal cortex with the following parameters: 10Hz, 50 trains (40 pulses on each train), biphasic wave, 25 seconds between the trains.

OTHERSham

The patients assigned to this group will undergo 10 sessions of rTMS but with an inactive coil, which will not generate electromagnetic pulses.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

No

Inclusion criteria

* Clinical and radiological diagnosis of traumatic brain injury. * Between one to two years after traumatic brain injuri * Must be able to sign the Informed Consent Form

Exclusion criteria

* Drug addiction * Uncontrolled epilepsy * Extensive Cranial vault defects

Design outcomes

Primary

Measure	Time frame
Evidence of improvement on Attentional processes measured by cognitive evaluation (Trail Making Test parts A and B; Stroop Test - Victoria Version; Symbol Digit Test)	One week and three months after rTMS.

Secondary

Measure	Time frame
Evidence of improvement on Executive Function processes measured by cognitive evaluation.	one week and 3 months.
Evidence of improvement on Motor Coordination measured by cognitive evaluation.	one week and three months.
Changes in cortical excitability measured by single and paired-pulse TMS	one week and three months.

Countries

Brazil

Outcome results

None listed