Using Positive Pressure Ventilation for Preoxygenation During Panendoscopy.

Non Invasive Ventilation (NIV) Versus Spontaneous Breathing for Preoxygenation During Ear, Nose, and Throat (ENT) Panendoscopy. A Controlled, Prospective, Randomized Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02167334

Acronym

PANNIV

Enrollment

Registered

2014-06-19

Start date

2013-09-30

Completion date

2014-06-30

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ENT Cancer Screening

Keywords

panendoscopy, preoxygenation, non invasive ventilation

Brief summary

the aim of the study is to determine if Spontaneous Ventilation with Positive Pressure Ventilation (PPV) preoxygenation allows a longer non hypoxemic apnea time during panendoscopy compared to spontaneous breathing preoxygenation. the hypothesis is PPV extends the residual functional capacity of lung so it provides more oxygen during apnea.

Interventions

DEVICEpositive pressure ventilation

Positive Pressure Ventilation with a 4 cmH2O inhale pressure, a positive end-expiratory pressure of 4 cm H2O, a trigger 2, an inspiratory slope of 0, an inhaled oxygen fraction of 100% administered at a 10 L / min flow.

PROCEDUREOxygenation with simple breathing mask

Spontaneously breathing preoxygenation with adapted face mask, to restrict leakage, at 10L/min oxygen, with inhaled fraction of 100% and a 2 L balloon volume.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient going for scheduled panendoscopy under general anesthesia

Exclusion criteria

* BMI upper to 35 kg/m2 * pregnancy * requirement of jet ventilation * tracheostomy * acute respiratory failure: pneumonia, pulmonary embolism * health insurance careless

Design outcomes

Primary

Measure	Time frame	Description
non hypoxemic apnea time	up to 5 minutes after stopping oxygenation	time the oxygen saturation is going down to 90% during apnea

Secondary

Measure	Time frame	Description
surgical laryngoscopy frequency	up to 15 minutes after stopping oxygenation	number of stopped surgical laryngoscopy because of a low oxygen saturation under 90% with necessity to ventilate the patients during apnea
preoxygenation time	up to 10 min after the start of oxygenation	time to reach expired oxygen fraction to 90%

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 3, 2026