Cognition, Essence of Chicken, Immunity, Metabolism, Stress Associated Cognitive Inhibition
Conditions
Keywords
Essence of Chicken, stress, cognitive function
Brief summary
The purpose of this study is to determine whether BRAND'S® Essence of Chicken are effective in the promotion of resilience and resistance to stress-associated cognitive inhibition.
Detailed description
This is a placebo-controlled, randomized, double-blind trial. There will be 100 subjects. Subjects are randomly assigned into either placebo or BRAND'S® Essence of Chicken (BEC), 70cc daily for 2 weeks, group. Stress test, cognitive function assessment and blood tests will be carried out at Week 0, Week 2, and Week 4 (2 weeks after termination of supplementation). The primary end-point is the better improvement of cognitive function after supplement with BEC than placebo. The second endpoints include improvement of global health survey and changes of biomarkers related to stress and immunity.
Interventions
DIETARY_SUPPLEMENTChicken Essence
BRAND'S® Chicken Essence of 70cc daily for 2 weeks Placebo 70 cc daily for 2 weeks
Sponsors
Taipei Medical University Shuang Ho Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* aged over 20 years, * mildly stressed with Perceive Stress Scale (PSS) score higher than 25 * All the participants should not require medication for their mood disturbance affected by stress during the trial.
Exclusion criteria
* history of chronic diseases * any psychiatric or neurological diseases (e.g. depression) * other medical illnesses (e.g. stroke, diabetes, other cardiovascular diseases) * allergy history to chicken
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in cognitive function at week 2 and week 4 | baseline, week 2, week 4 | Working memory, Episodic memory, Attention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in biomarkers and and immunity related to stress at week 2 and week 4 | baseline, week 2, week 4 | ACTH, Cortisol, Melatonin, Glucose, BUN/CRE, GOT/GPT |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in global health survey at week 2 and week 4 | baseline, week 2, week 4 | chinese version of SF36 |
Countries
Taiwan
Contacts
Primary ContactMing-Show Hsieh, R.N.
Backup ContactChaur-Jong Hu, M.D.
Outcome results
None listed