Accuracy of CNAP PPV Under General Anaesthesia

Comparison of the Non-invasive CNAP Pulse Pressure Variation With the Invasive Gold Standard

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02166580

Enrollment

Registered

2014-06-18

Start date

2014-01-31

Completion date

2015-07-31

Last updated

2017-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anaesthesia

Brief summary

Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor. Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.

Detailed description

Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* major surgery * need for invasive arterial measurements

Exclusion criteria

* age under 18 * cardiac dysrhythmia * vascular pathology at punction site

Design outcomes

Primary

Measure	Time frame	Description
Cardiac output	1, 2, 5, 10, 15 and 20 minutes after volume challange and	Improvement of cardiac output dependent on PPV before volume challenge

Countries

Germany

Outcome results