Denture Stomatitis
Conditions
Keywords
Denture stomatitis, Dentures, Denture wearers
Brief summary
The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.
Interventions
DRUGNystatin
100 000 IU every 6 h as a suspension
Sponsors
Jagiellonian University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with dental prostheses used for at least 6 months, * Substantial portion of the oral mucosa covered by dental prosthesis.
Exclusion criteria
* acute inflammatory disorders other than denture-related stomatitis, neoplastic disease relapses or chemotherapy courses less than 5 years before the enrolment, * antibiotics in less than 4 weeks before the enrolment, * anti-inflammatory drugs (steroids and non-steroidal, excluding aspirin in doses less than 80 mg) in less than 2 months before the enrolment, * history of myocardial infarction, acute coronary incident or vascular inflammation in 5 weeks or less before the enrolment, * chronic haematological disorders and immunodeficiencies less than 5 weeks before the enrolment, * major medication changes less than 5 weeks before the enrolment or during study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in blood pressure | Within 48h Prior to denture-related stomatitis treatment; 48h after recovery from denture-related stomatitis; 2 months after recovery from denture-related stomatitis | Ambulatory Blood Pressure Monitoring System |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in endothelial function | Within 48h Prior to denture-related stomatitis treatment; 48h after recovery from denture-related stomatitis; 2 months after recovery from denture-related stomatitis | Flow Mediated Dilatation |
| Changes in immune cell subset populations from baseline | Within 48h Prior to denture-related stomatitis treatment; 48h after recovery from denture-related stomatitis; 2 months after recovery from denture-related stomatitis | Determination of cell subsets, activation markers and intracellular cytokine production |
Countries
Poland
Contacts
Primary ContactMarta Cześnikiewicz-Guzik, PhD
Outcome results
None listed