KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease

KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02165878

Acronym

KNOW-PedCKD

Enrollment

458

Registered

2014-06-18

Start date

2011-03-31

Completion date

2021-12-31

Last updated

2018-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease(CKD)

Keywords

Chronic kidney disease(CKD)

Brief summary

KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) is a nation-wide, ten-year longitudinal cohort study, launched in 2011. The aim of the study is to assess the characteristics and risk factors of progression and complications of CKD of Korea. Pediatric sub-cohort of KNOW-CKD is planned to enroll 450 children with CKD, stage I to V (pre-dialysis).

Detailed description

Seven major pediatric nephrology centers of Korea enrolled children younger than 20 years who had CKD. Medical history taking, questionaire assessment of socio-economic status, anthropometric measurement, and clinical assessment using laboratory and imaging tests were done. Outcome is development of LV hypertrophy or hypertension, growth, neuropsychological status, behavioral status, kidney growth, and quality of life.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 20 Years

Healthy volunteers

Inclusion criteria

* Age: \< 20 yr * CKD stage 1 through 5 of KDIGO guideline * predialysis

Exclusion criteria

\- Dialysis

Design outcomes

Primary

Measure	Time frame	Description
eGFR	10 years	eGFR in mL/min/1.73 m2

Secondary

Measure	Time frame	Description
Development of cardiovascular disease	10 years	Hypertrophy in g/m2
Metabolic bone disease	10 years	Bone Dexametry in z score
Growth	10 years	Height in z score
Health-related quality of life (HRQOL)	10 years	PedsQL 4.0 Generic Core Scale Module (Mapi Research Trust, on behalf of Dr James W. Varni, copyright owner of PedsQL™)
Cognitive skills and emotional development	10 years	K-WAIS score
Anemia	10 years	Anemia in g/dL

Countries

South Korea

Outcome results