Gait Analysis in Neurological Disorders
Conditions
Brief summary
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait profiles. These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.
Interventions
None listed
Sponsors
University of Zurich
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Patients: * age 18 - 80 * written, informed consent * one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis * Brain and whole spine T1, T2 & FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans Healthy subjects: * age 18 - 80 * written informed consent
Exclusion criteria
Patients: * Colour-blindness * Known to be pregnant or breastfeeding * Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol * Terminal diagnosis with life expectancy less than six months * Cognitive disturbance defined as MMSE \< 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease Healthy subjects: * Colour-blindness * Known to be pregnant or breastfeeding * Body mass index (weight in kg/height in metres squared) \>40 Unable to walk 50m within 6 minutes * Reliance on walking aids / prostheses for mobilisation * Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of gait parameter after injury to CNS | Timepoint 0 plus timepoint 6 months and 12 months |
Countries
Switzerland
Outcome results
None listed