Acute Kidney Injury
Conditions
Keywords
Inferior vena cava, Kidney injury, Ultrasound
Brief summary
This is an observational study that will examine the possibility of determining the type of Acute Kidney Injury (AKI) using bedside ultrasound machines.
Detailed description
The investigators hypothesize that different types of AKI (pre-renal, renal, and post-renal) are associated with different inferior vena cava diameters and collapsibility index. The investigators will include subjects ages 18-89 years with AKI (creatinine of 2mg/100ml or higher for less than 24 hours from baseline creatinine ≤1.2 or with unknown baseline creatinine). Standard of care treatment will not be different for patients taking part in this study. Participants will have bedside ultrasounds on days 0, 1, and 3, and baseline and follow-up data will be collected from medical records.
Interventions
None listed
Sponsors
Texas Tech University Health Sciences Center
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
1. Creatinine of 1.7 mg/100ml or higher for less than 24 hours from baseline creatinine ≤1.2 or with unknown baseline creatinine 2. Age range: 18-89 years 3. Age range ≥ 18
Exclusion criteria
1\. Only chronic renal disease will exclude a patient from our study regardless of past medical history and medications they are taking. (For the purposes of this study, any patient with creatinine higher than 1.2 mg /100ml for more than 24 hours will be identified as having chronic renal disease.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury | Day 1 of ICU admission | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury. |
| Percent Collapse of the Inferior Vena Cava in Patients With Acute Kidney Injury | Day 1 of ICU admission | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury and calculate the percent change between the maximum and minimum diameters. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Ultrasound of Acute Kidney Injury This study represents a convenience sample of patients admitted to a medical intensive care unit with laboratory evidence of acute kidney injury. This is a prospective study. There is one study group only. There is no randomization. | 30 |
| Total | 30 |
Baseline characteristics
| Characteristic | Ultrasound of Acute Kidney Injury |
|---|---|
| Age, Continuous | 62.4 years STANDARD_DEVIATION 16 |
| Region of Enrollment United States | 30 participants |
| Sex: Female, Male Female | 9 Participants |
| Sex: Female, Male Male | 21 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 30 |
| serious Total, serious adverse events | 0 / 30 |
Outcome results
Primary
Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury
The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury.
Time frame: Day 1 of ICU admission
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Ultrasound of Acute Kidney Injury | Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury | Maximum diameter | 1.8 cm | Standard Deviation 0.5 |
| Ultrasound of Acute Kidney Injury | Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury | Minimum diameter | 1.2 cm | Standard Deviation 0.6 |
Primary
Percent Collapse of the Inferior Vena Cava in Patients With Acute Kidney Injury
The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury and calculate the percent change between the maximum and minimum diameters.
Time frame: Day 1 of ICU admission
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Ultrasound of Acute Kidney Injury | Percent Collapse of the Inferior Vena Cava in Patients With Acute Kidney Injury | 32 Percent change | Standard Deviation 20 |