Exploration of Neuroimaging and Biochemical Prognostic Indicators for POCD

Exploration of Neuroimaging and Biochemical Prognostic Indicators for Post-operative Cognitive Dysfunction After Coronary Artery Bypass Graft

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02164669

Enrollment

Registered

2014-06-16

Start date

2013-05-31

Completion date

2014-06-30

Last updated

2014-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Postoperative Cognitive Dysfunction

Keywords

Inflammation, Coronary artery bypass graft, Magnetic Resonance Imaging

Brief summary

Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the underlying mechanisms and represent a promising precursory target for diagnosis and treatment of POCD.

Detailed description

Postoperative cognitive dysfunction (POCD) is one of the most common complications in patients undergoing cardiac surgery. POCD will not only increase the incidence of complications and mortality, but also influence the quality of life after discharging from the hospital. Many factors are associated with POCD, such as neuroinflammation, age, anesthetics, surgery stress response and genetic factors. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI, which could monitor the peripheral neuron spontaneous activity according to the ratio of oxyhemoglobin and deaeration hemoglobin in blood, will be used to investigate whether POCD is induced by the variance in neurons metabolism and spontaneous activity in brain regions. Meanwhile, biochemical indicators will be detected to explore the prompting indicators of POCD. The present study is aimed to represent a promising precursory target for diagnosis and treatment of POCD, and provide novel evidence and insights on the brain changes induced by POCD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Aged 18-80 years old * Underwent selective CABG surgery

Exclusion criteria

* History of central nervous system or psychiatric disorders * History of taking sedative, antidepressants, or alcoholism * MMSE score less than 23 * Visual or auditory disorders * Educated less than 7 years * Claustrophobia * Can not be supine * Can not tolerate iodinated contrast agents

Design outcomes

Primary

Measure	Time frame	Description
The brain structure changes	7 days postoperatively	Using BOLD fMRI to investigate the variance of mean diffusivity and FA in nerve conduction bundle

Secondary

Measure	Time frame	Description
Mini-Mental State Examination	preoperative and 7 days, 3 months and 1 years postoperative	Application of digital depth and breadth to test digital sign test Tracking the attachment test and assess depression self rating scale

Countries

China

Contacts

Primary ContactQiang Wang, MD,PhD

Wangqiang@fmmu.edu.cn+86-29-84775343

Outcome results