Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy
Conditions
Keywords
dexmedetomidine, postoperative bowel movement, laparoscopic gastrectomy
Brief summary
The investigators hypothesized that sympatholytic effect of dexmedetomidine would attenuate the hemodynamic instability and decrease in the splanchnic blood flow caused by pneumoperitoneum during laparoscopic surgery. This study is to investigate the effect of intraoperative dexmedetomidine infusion on postoperative bowel movement in patients undergoing laparoscopic gastrectomy.
Interventions
DRUGthe dexmedetomidine group
the dexmedetomidine group: dexmedetomidine infusion from induction of anesthesia to end of surgery
DRUGthe control group
saline infusion from induction of anesthesia to end of surgery
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ * gastric cancer patient undergoing laparoscopic gastrectomy
Exclusion criteria
* ASA physical status Ⅳ * bradycardia (\< 60 bpm), arrhythmia * uncompensated heart failure * hepatic failure (Child-Pugh score B 이상) * renal failure (eGFR MDRD \< 60 ml/min/1.73m2)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gas passing | up to 1 week | To evaluate the postoperative bowel movement, we will assess the time to first gas passing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sips of water time | up to 1 week | To evaluate the postoperative bowel movement, we will assess the time to resume water intake |
Other
| Measure | Time frame | Description |
|---|---|---|
| soft diet time | up to 1 week | To evaluate the postoperative bowel movement, we will assess the time to resume soft diet intake |
Countries
South Korea
Outcome results
None listed