Statin and Epidural Steroid Injection

Effect of Statin Use on Low Back Pain Steroid Injections.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02162940

Enrollment

300

Registered

2014-06-13

Start date

2012-04-30

Completion date

2013-12-31

Last updated

2014-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low Back Pain After Epidural Steroid Injection, Quality of Life After Epidural Steroid Injection

Keywords

low back pain, epidural steroid injection, statin, quality of life

Brief summary

The impact of statin use on response to epidural steroid injections remains unknown and may well increase the effect considering the substantial anti-inflammatory properties. We thus tested the primary hypothesis that patients taking statins before and after the procedure will have lower VAS scores compared to patients not on statins. Secondarily we tested the hypothesis that statin users will have improved quality of life evaluated with Short Form 36 (SF 36).

Detailed description

Low back pain is one of the most common complaints for physician office visits and is the most common disorder requiring interventional pain treatment in USA. Fluoroscopy-assisted transforaminal anterior epidural steroid injections (TAESI) are more commonly preferred for treatment of low back pain. Most of the time epidural steroid injections are supplemented with different analgesic combinations due to insufficient analgesia. Recent reports have revealed immunomodulatory and anti-inflammatory activities for statins in vivo and in vitro. Statins have very recently been shown to alleviate neuropathic pain in the rat model. However, the impact of statin use on response to epidural steroid injections remains unknown and may well increase the effect considering the substantial anti-inflammatory properties. We thus tested the primary hypothesis that patients taking statins before and after the procedure will have lower VAS scores compared to patients not on statins. Secondarily we tested the hypothesis that statin users will have improved quality of life evaluated with Short Form 36 (SF 36).

Interventions

OTHERVisual analogue score

Visual analogue score vas used to evaluate pain.

OTHERThe SF 36 test

The SF 36 test (SHORT FORM 36) was used to evaluate quality of life.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* indication for TAESI given by blinded pain physician

Exclusion criteria

* known allergy to steroids * indication for surgery * unstable opioid use * drug or alcohol abuse within 6 months

Design outcomes

Primary

Measure	Time frame
Low back pain after transforaminal epidural steroid injection assessed by VAS scale.	6 months

Secondary

Measure	Time frame
Quality of life was evaluated with SF 12 test.	6 months

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026