Endocrine Disorders
Conditions
Brief summary
Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.
Detailed description
Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.
Interventions
Sponsors
Stanford University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
3 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal subjects * Subjects with possible endocrine disorder
Exclusion criteria
* Tracheostomy or ventilator dependent * Gastrotomy tubed dependent or unable to eat/drink by mouth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary Cortisol | All collections are done within 48 hours |
Countries
United States
Outcome results
None listed