Is COPD a Risk Factor for Cardiovascular Disease?

Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02162095

Enrollment

162

Registered

2014-06-12

Start date

2014-06-30

Completion date

2014-12-31

Last updated

2015-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary disease, Coronary artery disease, Coronary calcium score

Brief summary

Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.

Detailed description

Patients with chronic obstructive pulmonary disease (COPD) suffer from significant cardiovascular morbidity and mortality. Coronary artery disease has often been linked causally to COPD, but the exact pathophysiological mechanisms underpinning this association remain speculative. A retrospective case-control study matching COPD patients and controls one to one for smoking history and conventional cardiovascular risk factors will be performed to study the association between COPD and cardiovascular outcomes. Filling in this knowledge gap may contribute to the understanding of the interplay between COPD and cardiovascular disease. The objective of this retrospective case-control study is to determine whether COPD might be a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and major adverse cardiovascular events independent of conventional cardiovascular risk factors.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.2013. * Coronary artery calcium score and left ventricular ejection fraction data available. * History of smoking (smoker or ex-smoker). * COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC \< 0.7). * Control group: Exclusion of chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC \> 0.7).

Exclusion criteria

* Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation. * Known congenital or structural heart disease. * Previous heart transplantation.

Design outcomes

Primary

Measure	Time frame	Description
Coronary calcium score in cardiac computed tomography	Up to one month	Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.

Secondary

Measure	Time frame	Description
Left ventricular ejection fraction in single-photon emission computed tomography	Up to one month	Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.
Major adverse cardiovascular events	Up to three months	Follow-up via telephone interview for major adverse cardiovascular events.

Countries

Switzerland

Outcome results