Obesity
Conditions
Keywords
Obesity, dietary restrictions, metabolism, nutrition, elderly
Brief summary
The prevalence of obesity is growing in elderly with heavy consequences in term of medical complications and mortality, so that this is nowadays an important public health issue. The major therapeutic solution is dietary restrictions, but and the advantages and the metabolic consequences are not well known in elderly. The MONA study main aim is to assess the metabolic changes in this population, after dietary restrictions, compared to young people.
Detailed description
Primary endpoint : Study the metabolic adaptations of the subcutaneous adipose tissue after a diet in elderly obese men compared to young obese men. Secondary endpoints : Study the metabolic adaptations of skeletal muscle, the genetic adaptations of subcutaneous adipose tissue and skeletal muscle, the inflammatory and fibrosis modifications of subcutaneous adipose tissue, the insulinosensibility modifications, the modifications on the physical composition, modifications of the energy expenditure in resting state and the oxidation of the substrata, study the lipoproteins metabolism and identify new biomarkers. All those endpoints are studied comparing elderly obese subjects versus young obese subjects.
Interventions
OTHERdietary restrictions
Dietary restrictions during 8 weeks
Sponsors
University Hospital, Toulouse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 30 \< years old \< 40 OR 60 \< years old \< 70 * obesity : 30 \< BMI \< 40 * stable blood pressure (diastolic \<90mmHg, systolic \< 140mmHg) * glycemia \< 1,26g/L, LDL cholest \<1,9-1,6g/L, Triglycerides \<2,5g/L * risk factors concerning high blood pressure, diabetes and dyslipidemia under control
Exclusion criteria
* Insulin dependent diabetes, non-insulin dependent diabetes * high blood pressure * dyslipidemia * history of cardiovascular diseases or bariatric surgery * undernutrition * HbA1C \>7% * non authorized treatments : Glucagon-like peptide-1 agonists, * incapacity to do physical activity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lipolysis at resting and during physical activity test | Change after 8 weeks dietary restrictions | Determine lipolysis at resting and during physical activity test by microdialysis, before dietary restrictions and after dietary restrictions (20% dietary restrictions) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic parameters in skeletal muscle | Change after 8 weeks dietary restrictions | To assess metabolic parameters before dietary restrictions and after dietary restrictions (20 % dietary restrictions) |
| Genetic markers | Change after 8 weeks dietary restrictions | To assess genetic markers in adipose tissue and skeletal tissue before dietary restrictions and after dietary restrictions |
| Fibrosis and inflammatory markers in adipose tissue | Change after 8 weeks dietary restrictions | To assess markers in adipose tissue before dietary restrictions and after dietary restrictions (20 % dietary restrictions) |
| insulinosensibility | Change after 8 weeks dietary restrictions | To determine insulinosensibility before dietary restrictions and after dietary restrictions (20 % dietary restrictions) |
| Fat and muscles rates in the whole body | Change after 8 weeks dietary restrictions | To determine fat and muscles rates by Dexa before dietary restrictions and after dietary restrictions |
| Energetic consumption | Change after 8 weeks dietary restrictions | energetic consumption at resting and during physical activity, before dietary restrictions and after dietary restrictions |
| Lipoproteins metabolism | Change after 8 weeks dietary restrictions | Before dietary restrictions and after dietary restrictions |
| biomarkers identification | Change after 8 weeks dietary restrictions | New urinary and intestinal biomarkers identification, before dietary restrictions and after dietary restrictions |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORClaire Thalamas, MD PhD
University Hospital, Toulouse
Outcome results
None listed