Obesity
Conditions
Keywords
Obesity, Gastric Bypass, Bariatric Surgery, Incretin Function, Islet Function
Brief summary
To examine pancreatic islet function and incretin function during intravenous and oral stimulation \>2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.
Interventions
None listed
Sponsors
Hvidovre University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Participation in previous study (NCT01559779)
Exclusion criteria
* Pregnancy/lactation * Major chronic disease develop since previous examination with possible impact on outcomes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in islet cell function from baseline (preoperatively) | >24 months | Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in glucose tolerance during oral glucose tolerance test | >24 months | Fasting, peak and nadir glucose during oral glucose tolerance test |
| Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass | >24 months | Differences in arterial and venous plasma glucose during oral glucose stimulation |
Countries
Denmark
Outcome results
None listed