Coarctation of the Aorta, Tetralogy of Fallot, Transposition of the Great Arteries
Conditions
Keywords
Atria, Heart, Function, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Congenital Abnormalities, Tetralogy, Fallot, Transposition of Great Arteries, Coarctation of the Aorta
Brief summary
The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart disease.
Detailed description
Atrial function is important for good ventricular filling and function. In patients with impaired cardiac function, atrial contraction is even more important. So far, the size and function of the atria have been assessed two-dimensionally by angiography and by echocardiography. However, these do not allow exact characterization of the volumetric changes of the atria during the cardiac cycle. Recently, cardiac magnetic resonance (CMR) has been used to assess size and function of the left atrium in adults. Little data are available about function and volume of the atria in children and the role of the atria in congenital heart disease (CHD). The study will recruit patients with CHD (n=40) and normal controls (n=10). The patient group will be composed by patients suffering from the following conditions: coarctation of the aorta (n=10), tetralogy of Fallot (n=10), transposition of the great arteries after atrial switch (Senning procedure) (n=10), transposition of the great arteries after arterial switch operation (n=10). The study consists of measurements of sizes and function of the right and the left atrium, respectively, by examining three-dimensional volume changes across the heart cycle, and of phase contrast measurements of blood flow across the valves of the heart.
Interventions
None listed
Sponsors
University Children's Hospital, Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Ability to perform repetitive breath holds of 10-15 seconds each * Written informed consent of the patients or their legal guardians
Exclusion criteria
* Patients requiring general anaesthesia * Residual cardiac findings which might potentially influence the size and function of the atria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Right and left atrial volume | Day of CMR (baseline only, no intervention) | Measurement of maximal volume (at end of systole), volume before atrial contraction (in late diastole), and minimal volume (at end of diastole) of both atria. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow across the atrio-ventricular valves | Day of CMR (baseline only, no intervention) | Phase contrast measurement of blood flow across the atrio-ventricular and the ventriculo-arterial valves, respectively, to serve as an internal validation of total atrial emptying volumes, as well as to contribute maximum early and late diastolic velocities. |
Countries
Switzerland
Outcome results
None listed