The Effect of Blood Transfusion on Endothelial Function

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02161042

Enrollment

Registered

2014-06-11

Start date

2011-08-31

Completion date

2016-06-30

Last updated

2016-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia, MDS

Keywords

Blood transfusion, Storage Lesion, Endothelial dysfunction, Nitric Oxide

Brief summary

Blood transfusion is often used to treat patients with Anemia. The period of storage of blood products prior to use for transfusion may vary. Prolonged storage of blood products may result in changing their biochemistry. This study aims to look into whether the transfusion of old blood, which is stored for more than 7 days, as compared to the transfusion of Fresh blood, which is stored for less than 7 days, will affect endothelial function.

Detailed description

Endothelial function assessed pre and post transfusion. The EndoPAT uses a unique bio-sensors that are placed on the fingertips to measure pressure. The test takes about 20-25 minutes. During the procedure the participant will have biosensors placed on the index finger of each hand. The nondominant arm will have a blood pressure cuff applied with sufficient pressure for five minutes. At the end of the test the device will provide a reading that assesses the level of endothelial function/dysfunction.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 95 Years

Healthy volunteers

Inclusion criteria

* Age is \> 18 years * Need recurrent blood transfusion

Exclusion criteria

* Latex Allergy * Life expectancy is less than 6 months * History or evidence of drug or alcohol abuse in the last 12 months * Any medical condition that will place the participant at a higher risk if they participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Endothelial function	Change in endothelial function compared to baseline. Test is done 15 minutes prior to transfusion and 30 minutes post blood transfusion. The test is repeated when patient received another blood transfusion. The results of the change are compared.	The function of the blood vessels will be assessed with the EndoPAT device. This test is done 15 minutes prior to the transfusion and again 30 minutes post the transfusion. Patients that will receive both fresh and old blood will be included.

Countries

Canada

Outcome results