Risk of Diabetes in Young Turner Syndrome Patients

Beta-Cell Function in Young Turner Syndrome Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02160717

Enrollment

120

Registered

2014-06-11

Start date

2014-05-31

Completion date

2017-06-30

Last updated

2017-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Turner Syndrome

Keywords

Turner Syndrome, Diabetes

Brief summary

Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.

Detailed description

The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

6 Years to 22 Years

Healthy volunteers

Yes

Inclusion criteria

Turner Syndrome Females: Inclusion Criteria: * Turner Syndrome confirmed by chromosomal testing * On standard therapy (growth hormone and or estrogen)

Exclusion criteria

* Type 1 or Type 2 diabetes * Polycystic Ovarian Syndrome * Pregnancy * On any medications that alter blood sugar Healthy Female Controls: Inclusion Criteria: * Healthy

Design outcomes

Primary

Measure	Time frame	Description
Beta-Cell Function measured as Disposition Index	1 day at screening	Disposition index will be calculated based on the results of the oral glucose tolerance test using minimal modeling (computer program)

Countries

United States

Outcome results