Chronic Periodontitis
Conditions
Keywords
Osteoprotegerin, Biomarker, Chronic periodontitis, Open flap debridement
Brief summary
The study hypothesis: Is Osteoprotegerin a diagnostic and/or prognostic marker of periodontal disease?
Detailed description
assessment of osteoprotegerin in patients with chronic periodontitis before and after periodontal surgery in gingival crevicular fluid, saliva and gingival tissues.
Interventions
PROCEDUREOpen flap debridement
an access flap
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
32 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* severe chronic periodontitis, having pocket depth of ≥ 5 mm and clinical attachment level ≥ 5 mm
Exclusion criteria
* pregnant women * subjects had \<22 permanent teeth * having any given systemic disease * taking any type of medication and/or antibiotic therapy during the 3 months before the study * received periodontal treatment within the past 12 months * current or former smokers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in Osteoprotegerin levels at 3 and 6 months | Baseline, 3 months and 6 months |
Secondary
| Measure | Time frame |
|---|---|
| changes from baseline in Clinical attachment level at 3 and 6 months. | Baseline, 3 months and 6 months |
| Changes from baseline in probing pocket depth at 3 and 6 months | baseline, 3 months and 6 months |
| Changes from baseline in plaque index at 3 and 6 months | baseline, 3 months and 6 months |
| Changes from baseline in gingival index at 3 and 6 months | baseline, 3 months and 6 months |
Countries
Egypt
Outcome results
None listed