Obesity
Conditions
Keywords
roux-en-Y-gastric bypass, brain responses to food, gastrointestinal hormones, bile acids
Brief summary
This is a cross-sectional study enrolling * 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB) * 11 age- and weight-matched female subjects * 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal * electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures * plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are * to evaluate the effects of RYGB on brain perception of food related visual stimulation * to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion
Interventions
OTHERstandard test meal
Sponsors
University of Lausanne
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* good apparent health * gender: female * age 18-50 * non-smoker
Exclusion criteria
* diabetes or antidiabetic medication * consumption of more than 50g alcohol per week * vegetarian or any special diet
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of visually-evoked EEG potentials after ingestion of a meal | basal, 120 min postprandial and 240 postprandial | Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in plasma triglyceride concentration after ingestion of a meal | basal, 90 min postprandial and 180 postprandial | Measurement of triglyceride concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
| Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal | basal, 90 min postprandial and 180 postprandial | Measurement of GLP1 and GIP concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
| Changes in plasma cholecystokinin concentrations after ingestion of a meal | basal, 90 min postprandial and 180 postprandial | Measurement of cholecystokinin concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
| Changes in plasma bile acids concentrations after ingestion of a meal | basal, 90 min postprandial and 180 postprandial | Measurement of bile acids concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
| changes in plasma glucoregulatory status after ingestion of a meal | basal, 90 min postprandial and 180 postprandial | Measurement of glucose, insulin, glucagon and non-esterified fatty acid concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
Countries
Switzerland
Outcome results
None listed