Nutrition Disorders
Conditions
Brief summary
1. Nutritional support during critical illness is important to improve the clinical outcome of patients. Recently, the apply of early enteral nutrition is recommend in critically ill patients on basis of data that enteral nutrition can be helpful to prevent the hospital-acquired infections. * However, in critically ill patients, the smooth progress of nutritional support is often hindered by gastrointestinal intolerance, underlying clinical condition, and temporal necessity of procedure or operation. * Continuous feeding method, compared with intermittent feeding, is expected to reduce the risk of gastrointestinal intolerance, and improve the nutritional support, but this hypothesis is not supported by appropriate evidences. 2. We will elucidate to compare the efficacy and safety of the continuous feeding method in critically ill patients, compared with the intermittent feeding method. * Prospective, randomized controlled study * Primary outcome: the achievement rate of target nutritional goal within 7 days after the start of enteral nutrition * Secondary outcome: gastrointestinal tolerance, In-ICU/hospital mortality, frequency of hospital-acquired infection, ICU/hospital length-of-stay, duration of mechanical ventilation
Interventions
OTHERContinuous enteral feeding via infusion pump
OTHERIntermittent enteral feeding via gravity-based infusion
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patient admitted in the intensive care unit * age 20 years old or more * The enteral nutritional support is expected to be available within 48 hours after ICU admission
Exclusion criteria
* previous abdominal surgery within 1 month * gastrointestinal bleeding, bowel obstruction, refractory vomiting/diarrhea * hypersensitivity to prokinetics, history of seizure or phechromocytoma * enteral feeding via enterostomy or gastrostomy * difficulty to insert or maintain nasogastric tube * need for specialized feeding (ex: hemodialysis diet, chronic renal failure diet, diabetes diet) * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Achievement rate of target nutritional goal | Within 7 days after the start of enteral feeding |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal tolerance | Within 7 days after start of enteral feeding |
| ICU/hospital mortality | During hospital admission |
| Frequency of hospital-aquired infection | During hospital admission |
| ICU/hospital length-of-stay | During hospital admission |
| Duration of mechanical ventilation | During hospital admission |
Countries
South Korea
Outcome results
None listed