Anxiety, Depression, Hereditary AngioEdema
Conditions
Brief summary
Since 1963 Hereditary AngioEdema (HAE) is considered an autosomal dominant disorder (Donaldson and Evans), characterized by a quantitative and/or qualitative deficit of C1 esterase inhibitor (C1-INH), which affects approximately 1:50.000 individuals in the general population. From this period the link between HAE and psychiatry was interrupted, however genetic issues could not comprehensively explain the clinical evolution of the disease. Clinical studies show an evident gap between genotype and phenotype of HAE. For this still controversial question, we have designed this cross-sectional study in order to establish the relationship between HAE clinical manifestations and neurobiological/psychopatological parameters.
Interventions
OTHERClinical and psychopathological assessment of HAE patients
Sponsors
University Hospital, Catania
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Diagnosis of HAE
Exclusion criteria
* Current pharmacological treatment including ACE-inhibitors, ACE inhibitors, glucocorticoids, oestroprogestative, psychotropic drugs, drugs acting on the immune system (15 days before), anesthetics (in the previous three months). * Inflammation / infection (eg, chronic inflammatory diseases, acute) in the last 15 days. * Ongoing allergies. * Night work over the past 15 days. * Vigorous physical activity or alcohol consumption (the day before the assessment). * Women in follicular phase of menstrual cycle.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multivariate linear regression analysis of HAE clinical status and psychometric parameters | First assessment |
Countries
Italy
Contacts
Primary ContactGiuseppe Minutolo, MD, PhD
Backup ContactFrancesca Magnano S. Lio, MD
Outcome results
None listed