Autoimmune Hemolytic Anemia
Conditions
Brief summary
Autoimmune hemolytic anemia (AIHA) is an auto-immune disease mediated by specific antibodies targeting red blood cells. Its pathogenesis is not completely understood, and the role of T cells have been rarely studied. The aim of this study is to compare the frequency of circulating T cells, T cell polarization and functions, notably regulatory T cells, during warm AIHA by comparison to healthy controls. The role of treatments, such as steroids, will also be determined in patients with warm AIHA.
Interventions
BIOLOGICALblood samples
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients diagnosed with primary warm Autoimmune Hemolytic Anemia (wAIHA) * Secondary AHAI (infections, hematological diseases, systemic diseases) * Naive of treatment for hemolytic anemia or in relapse * Older than 16 * Able to understand written and spoken French * who have provided written informed consent * INCLUSION CRITERIA for CONTROLS * Persons without auto-immune disease, cancer or active infection. * Older than 16 * Able to understand written and spoken French * who have provided written informed consent
Exclusion criteria
* Cold agglutinin disease * Pregnancy * Persons without national health insurance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physiological parameter : blood level of regulatory T cells (Treg, CD4+CD25HighFoxp3+) | Change from baseline to 3 months |
| physiological parameter : percentage of inhibiting LT proliferation inhibition | Change from baseline to 3 months |
Countries
France
Outcome results
None listed