Effect of Aerobic Training in Patients With Oculopharyngeal Muscular Dystrophy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02158156

Enrollment

Registered

2014-06-06

Start date

2014-02-28

Completion date

2015-02-28

Last updated

2014-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oculopharyngeal Muscular Dystrophy

Brief summary

The investigators want to investigate if patients with Oculopharyngeal Muscular Dystrophy can improve fitness by home-training on a cycle ergometer 30 minute, 3 times a week for 10 weeks. Participants will be evaluated on maximal oxygen consumption and maximal workload measured by an incremental test at baseline and at the end of the exercise period.

Interventions

BEHAVIORALExercise

Ten weeks of home-training on a cycle ergometer 3 times a week for 30 minutes.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Danish patients with Oculopharyngeal muscular dystrophy

Exclusion criteria

* Patients who are too week to train on an cycle-ergometer for 10 weeks * Patients with other health issues wich confound the interpretation of the efficacy.

Design outcomes

Primary

Measure	Time frame	Description
Efficacy based on VO2max	10 weeks	Difference in VO2max measured before and after intervention

Secondary

Measure	Time frame	Description
6 minute walk test	10 weeks	Changes in walking distance from baseline to end of intervention
Intensity in maximal load (Watt)	10 weeks	Changes in maximal load (watt) in the VO2max-test from baseline to end of intervention.
Level of plasma creatine kinase	10 weeks	Marker for exercise-induced muscle damage. Taken week 0,3 and 10.
SF-36 Questionaire	10 weeks	Changes in self-rated health from baseline to end of intervention
A five-time-repetition-sit-to-stand-test	10 weeks	Changes in time of five repetitions from baseline to end of intervention
A 14-step-stair-test	10 weeks	Changes in time completing the test from baseline to end of intervention
Dynamometry	10 weeks	Changes in external force production from baseline to end of intervention. Dynamometry are measured on hip flexion, dorsal foot flexion, plantar foot flexion, knee flexion, knee extension, and elbow flexion.
Level of plasma myoglobin	10 weeks	Marker for excercise-induced muscle damage, taken week 0, 3 and 10.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026