Chronic Kidney Disease
Conditions
Keywords
exercise, rehabilitation, kidney function, cardiovascular disease risk
Brief summary
The proposed research aims to examine whether regular aerobic exercise can preserve renal function, improve aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life. Ultimately, the research aims to prove that exercise is a more cost-effective and a more efficient use or healthcare resources used in the treatment of patients with CKD. Exercise is a relatively cheap treatment option which is readily available and accessible for this patient population. establish if, compared with usual care, an exercise programme for pre-dialysis CKD patients; 1. Preserves renal function. 2. Improves aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life.
Interventions
OTHERExercise
The intervention will include 2 sessions of gym-based exercise per week, both of which will be supervised for 3 months, supervision will then decrease to once-weekly until 6 months, and then be through phone support for the remaining 6 months. Warm up and cool down of minimum of five minutes on stationary exercise cycle, rate of perceived exertion (RPE) \ 11, followed by gentle stretching. Progressive resistance training (PRT) will use eight PRT machines training large muscle groups (e.g. bench press, latissimus pulldown, bicep curl, triceps pull down, leg press, knee extension, hamstring curl, calf raises). Intensity will be 80% of one repetition maximum (1RM), building up to 3 sets of 8 repetitions. 1RM will be re-assessed monthly, and program adjusted accordingly.
Sponsors
King's College Hospital NHS Trust
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \- Stages 3-4 chronic kidney disease (CKD) patients (glomerular filtration rate (GFR) 20-60 mL/min) * Male or female * Aged \>18 years * Written informed consent
Exclusion criteria
* Pregnancy * Requiring support for ambulation less than 20m * Vasculitis, * Proliferative diabetic retinopathy, * Severe osteodystrophy, * Uncontrolled diabetes, * Psychiatric illness, including anxiety, mood and untreated eating disorders * Infection or course of antibiotics within the last month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| kidney function | up to 12 months | estimated glomerular filtration rate (egfr) creatinine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pulse Wave Velocity (arterial stiffness) | Baseline, 6 and 12 months | Vicorder equipment, carotid-femoral region. |
| Body mass index (BMI) | Baseline, 6 and 12 months | — |
| weight | Baseline, 6 and 12 months | — |
| Waist circumference | Baseline, 6 and 12 months | — |
| Duke's activity status index | Baseline, 6 and 12 months | questionnaire |
| Cardio-respiratory fitness testing (VO2peak) | Baseline, 6 and 12 months | cycle ergometer |
| Total cholesterol | Baseline, 6 and 12 months | — |
| High sensitivity c-reactive protein (Hs CRP) | Baseline, 6 and 12 months | — |
| Blood pressure | Baseline, 6 and 12 months | — |
| Resting heart rate (HR) | Baseline, 6 and 12 months | — |
| Triglycerides | baseline, 6 and 12 months | — |
| Short Form 36 questionnaire | Baseline, 6 and 12 months | — |
Countries
United Kingdom
Outcome results
None listed