The Effect of Ketamine Infusion on Lumbar Surgery

The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02154438

Enrollment

Registered

2014-06-03

Start date

2014-05-31

Completion date

2015-04-30

Last updated

2014-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Low Back Pain

Brief summary

The purpose of this study is to evaluate the effect of ketamine infusion for reduction of neuropathic pain and improvement of quality of life after lumbar surgery.

Detailed description

Neuropathic pain defined as 'pain caused by a lesion or disease of the somatosensory system'. Neuropathic pain is 20 - 35% of low back pain. Ketamine is categorized as N-methyl D-aspartate receptor antagonist. Ketamine has an analgesic effect in low dose and anesthetic effect in relative high dose. Also, ketamine is used in chronic neuropathic pain as postherpetic neuralgia., phantom pain, central neuropathic pain, complex regional pain syndrome, ischemic pain. In this study, ketamine will be infused during lumbar surgery in randomized, double-blind and double-blind parallel group control trial.

Interventions

DRUGKetamine

ketamine 0.5mg/kg loading followed by 0.5mg/kg/h infusion during operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Undergoing lumbar spine surgery due to back pain patients * American Physical Status Classification I or II

Exclusion criteria

* less than 3 month of back pain * past history of operation at lumbar area * past history of glucoma, drug abuse, alcohol abuse * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Pain Scores on the Visual Analog Scale	1 day before lumbar surgery	VAS score in 1 day before lumbar surgery

Secondary

Measure	Time frame	Description
Leeds assessment of neuropathic symptoms and signs (LANSS) score	1 day before lumbar surgery	LANSS score in 1 day before lumbar surgery
neuropathic pain scale (NPS) score	1 day before lumbar surgery	NPS score in 1 day before lumbar surgery
Oswestry disability index (ODI) score	1 day before lumbar surgery	ODI score in 1 day before lumbar surgery
WHO Quality of Life (WHOQOL-BREF) score	1 day before lumbar surgery	WHOQOL-BREF score in 1 day before lumbar surgery

Countries

South Korea

Contacts

Primary ContactKyung Hyun Kim, MD

NSKHK@yuhs.ac82-02-2019-3401

Backup ContactCholhee Park, MD

chairp@yuhs.ac82-02-2019-6079

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026