Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02154074

Enrollment

Registered

2014-06-03

Start date

2014-05-31

Completion date

2014-10-31

Last updated

2014-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Blood Glucose and Insulin

Keywords

Dexmedetomidine perioperative blood glucose and insulin

Brief summary

Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period. Dexmedetomidine have influence on perioperative stress response and immune function,but it is not clear.

Interventions

DRUGgeneral anesthesia induction

general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg

DRUGIsoflurane

inhale Isoflurane 1.5MAC

DRUGDexmedetomidine

anesthesia induction period: intravenous pumping Dexmedetomidine 4ug/Kg/h; after 10 minutes,turn to 0.4ug/Kg/h.

DRUGnormal saline

the same volume of saline + Isoflurane during operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Aged 60 to 80 years old; * Type 2 diabetes; * Not use insulin treatment; * Onging general anesthesia surgery; * Surgery time 1-3 hours

Exclusion criteria

* ASA classification \> class II; * Hypertension; * Serious central nervous system diseases (acute stroke, uncontrolled seizures, -Severe dementia); * Unstable angina and acute myocardial infarction; * Allergy to investigational drug; * Hepatic and renal dysfunction

Design outcomes

Primary

Measure	Time frame	Description
blood glucose	from the day before surgery to 24 hours after surgery	measure blood glucose at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); examine the concentration of blood glucose in serum.
level of blood insulin	from the day before surgery to 24 hours after surgery	measure the level of blood insulin at 3 time points,the day before surgery,Intraoperative(1 hour after surgery begain),one day after surgery(24 hours after surgery); use ELISA to examine the concentration of blood insulin in serum.

Secondary

Measure	Time frame	Description
vital signs	duration of perioperative period	measure the blood pressure(BP),heart rate(HR) and oxygen saturation(SpO2) in the perioperative period

Countries

China

Contacts

Primary ContactHongtao Liu

lannylouis@163.com13572225310

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026