Stroke
Conditions
Keywords
Aphasia, Anomia
Brief summary
This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called aphasia. Individuals in this study will receive one of two treatments. The first is a phonological (sound level) treatment and the second is a semantic (word level) treatment. Individuals in both groups will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).
Detailed description
Purpose: The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session as well as generalization to untrained exemplars and contexts. Phonomotor treatment (PMT) has shown such effects but has not yet been compared to a commonly used lexical/semantic based treatment (semantic feature analysis; SFA). Methods: In a between group randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56-60 hours of intensively delivered treatment over 6 weeks with testing pre-, post- and three-months post treatment termination.
Interventions
BEHAVIORALSemantic Feature Analysis therapy
Control therapy; current standard of care therapy
BEHAVIORALPhonomotor Therapy
Experimental therapy.
Sponsors
Portland State University
University of Washington
VA Office of Research and Development
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Single, left-hemisphere stroke * English as primary language prior to stroke
Exclusion criteria
* Other neurological disorders * Untreated depression
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spoken Word Production (Confrontation Naming) | Pretreatment to 3 months following treatment termination change | Reporting a change in percent correct scores pre-treatment versus 3-months post treatment. (0-100% scale) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Response Latency | Pretreatment to 3 months following treatment termination change | Change in response latency of confrontation naming pre-treatment versus 3 months post treatment. |
| Verbs Correctly Named | Pretreatment to 3 months following treatment termination change | Change in confrontation naming of verbs were scored for accuracy and percent correct (0% to 100%) was analyzed before versus 3 months post treatment. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Phonomotor Therapy Experimental group
Phonomotor Therapy: Experimental therapy. | 28 |
| Semantic Feature Analysis Therapy Current standard of care therapy
Semantic Feature Analysis therapy: Control therapy; current standard of care therapy | 30 |
| Total | 58 |
Baseline characteristics
| Characteristic | Phonomotor Therapy | Semantic Feature Analysis Therapy | Total |
|---|---|---|---|
| Age, Continuous | 63.3 years STANDARD_DEVIATION 10.6 | 63.4 years STANDARD_DEVIATION 12.3 | 63.35 years STANDARD_DEVIATION 0.07 |
| Race (NIH/OMB) American Indian or Alaska Native | — | — | 0 Participants |
| Race (NIH/OMB) Asian | — | — | 0 Participants |
| Race (NIH/OMB) Black or African American | — | — | 0 Participants |
| Race (NIH/OMB) More than one race | — | — | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | — | — | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | — | — | 0 Participants |
| Race (NIH/OMB) White | — | — | 0 Participants |
| Region of Enrollment United States | 28 Participants | 30 Participants | 58 Participants |
| Sex: Female, Male Female | 13 Participants | 12 Participants | 25 Participants |
| Sex: Female, Male Male | 15 Participants | 18 Participants | 33 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 28 | 0 / 30 |
| other Total, other adverse events | 0 / 28 | 0 / 30 |
| serious Total, serious adverse events | 0 / 28 | 0 / 30 |
Outcome results
Primary
Spoken Word Production (Confrontation Naming)
Reporting a change in percent correct scores pre-treatment versus 3-months post treatment. (0-100% scale)
Time frame: Pretreatment to 3 months following treatment termination change
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Phonomotor Therapy | Spoken Word Production (Confrontation Naming) | 53.01 percent correct | Standard Deviation 29.71 |
| Semantic Feature Analysis Therapy | Spoken Word Production (Confrontation Naming) | 50.37 percent correct | Standard Deviation 29.79 |
Secondary
Response Latency
Change in response latency of confrontation naming pre-treatment versus 3 months post treatment.
Time frame: Pretreatment to 3 months following treatment termination change
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Phonomotor Therapy | Response Latency | 1.49 seconds | Standard Deviation 0.54 |
| Semantic Feature Analysis Therapy | Response Latency | 1.40 seconds | Standard Deviation 0.67 |
Secondary
Verbs Correctly Named
Change in confrontation naming of verbs were scored for accuracy and percent correct (0% to 100%) was analyzed before versus 3 months post treatment.
Time frame: Pretreatment to 3 months following treatment termination change
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Phonomotor Therapy | Verbs Correctly Named | 3.36 percent correct | Standard Deviation 7.19 |
| Semantic Feature Analysis Therapy | Verbs Correctly Named | 2.46 percent correct | Standard Deviation 9.11 |