Major Depressive Disorder
Conditions
Keywords
Depression, Positron Emission Tomography (PET), MAO-B
Brief summary
The purpose of this study is to determine if monoamine oxidase B (MAO-B) total distribution volume (VT), after phenelzine treatment and if so to what extent.
Detailed description
Subjects will receive a PET and MRI scan before and after treatment with phenelzine.
Interventions
OTHERphenelzine treatment
Subjects will have a PET and MRI scan before and after treatment with phenelzine.
Sponsors
Centre for Addiction and Mental Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 18-80 years of age * good physical health * Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of current major depressive episode (MDE) * DSM-IV diagnosis of major depressive disorder (MDD) verified by SCID for DSM-IV and a psychiatric consultation * greater than 17 on the 17 item HDRS (Hamilton Depression Rating Scale). * history of non-response to several different antidepressant classes
Exclusion criteria
* herbal, drug or medication use (that affect CNS function) * suicide attempts * drug or medication use within eight weeks (+5 half lives of medication) * history of substance abuse or any neurotoxin use * history of psychotic symptoms * history of central nervous system (CNS) medical illness * current substance abuse * test positive on pregnancy test (for women)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAO-B VT levels measured with PET in MDE secondary to MDD | 8 weeks |
Countries
Canada
Outcome results
None listed