The Effects of Selective Site Right Ventricular Pacing

Does a Surrogate Marker Exist That Can be Used as A Predictor For Left Ventricular Dysfunction In Patients Undergoing Right Ventricular Pacing

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02153242

Acronym

PacingRV

Enrollment

Registered

2014-06-03

Start date

2013-09-30

Completion date

2015-06-30

Last updated

2020-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bradycardia

Keywords

Pacing, Haemodynamics, Pilot

Brief summary

This is a pilot study into the effects on heart function when pacing the right ventricle (RV). This study aims to enrol a population with structurally normal hearts. The investigators aim to measure heart function directly when pacing. When normal conduction within the heart fails, the treatment may be to implant a permanent pacemaker. Pacing involves passing a lead via a vein to the heart and using an electrical impulse to stimulate a beat. The usual site for pacing is the tip of the RV. This has been shown to be less efficient than the normal conduction system of the heart and in some cases leads to markedly reduced function. What the investigators do not know is why this is the case. Much effort has been directed at looking at features within the left ventricle (LV) for markers of disease progression but little has been investigated regarding the RV. There may be some benefit to pacing the heart preferentially from different parts of the RV and the investigators aim to measure if any differences are detectable from stimulating the heart at various sites within the RV.

Detailed description

Inclusion Criteria; * Patients undergoing elective Electrophysiological Studies +/Ablation * Age 18-80 * Normal Heart on Pre-procedural Echocardiogram Exclusion criteria; * Atrial Fibrillation * Evidence of anterograde conducting accessory pathway * Permanent Pacemaker insitu * Pregnant * Breast Feeding Outcome Measures; Change in load-independent indices of LV and RV contractility before and after pacing intervention. LV and RV function measured by transthoracic echocardiography and tissue Doppler imaging.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing elective Electrophysiological Studies +/Ablation * Age 18-80 * Normal Heart on Pre-procedural Echocardiogram

Exclusion criteria

* Atrial Fibrillation * Evidence of anterograde conducting accessory pathway * Permanent Pacemaker insitu * Pregnant * Breast Feeding

Design outcomes

Primary

Measure	Time frame	Description
Ventricular Function	30 minutes	Measurement of both right and left ventricular function under differing pacing conditions

Countries

United Kingdom

Outcome results