Acne
Conditions
Keywords
medication
Brief summary
For the chemical lupeol isolated from eggplant, we applied it to one side of face, and applied vehicle control to another side for 8 -weeks. The study was performed in a 8-week, randomized controlled, split face fashion. Investigators evaluated safety and efficacy during baseline, 2 weeks, 4weeks, and 8 weeks after beginning of study.
Interventions
DRUGLupeol
Patients are supposed to apply lupeol cream to one side of their face two times per day for 8 weeks.
DRUGControl vehicle
Patients are supposed to apply their control vehicle to the other side of their face for 8 weeks
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients over the age 15 who were clinically diagnosed with mild to moderate acne vulgaris
Exclusion criteria
* ; known pregnancy or lactation, any medical illness that might influence the results of the study, a previous history of oral acne medication or surgical procedures including laser treatment within 6 month and topical medication within 4 weeks of study enrollment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acne lesion counts as a measure of efficacy | 8 weeks after beginning of applications | Both inflammatory & non-inflammatory acne lesions of both of their facial sides |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability | 8 weeks after beggning of applications | Among total patients enrolled in this study, number of patients either experiencing objective adverse events or subjective uncomfortableness were counted |
Countries
South Korea
Outcome results
None listed