Healthy
Conditions
Brief summary
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method
Interventions
BEHAVIORALResistance Exercise
6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets
Sponsors
Physiological Society
University of Nottingham
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active
Exclusion criteria
* Active cardiovascular disease * Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial) * Respiratory disease including pulmonary hypertension or COPD * Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes * Active inflammatory bowel disease * Renal disease * Malignancy * Recent steroid treatment (within 6 mo), or hormone replacement therapy * Clotting dysfunction * Musculoskeletal or neurological disorders * Any disease requiring long-term drug prescriptions, including statins
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle Protein Synthesis | 0-6 Weeks | Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle Sub fractions | 0-6 week | Comparison of different sub fractions involved in muscle mass regulation between young and older individuals and in response unilateral exercise training |
Other
| Measure | Time frame | Description |
|---|---|---|
| Muscle Functions | 0-6 Weeks | Muscle Strength and power un young and older individuals in response to unilateral exercise training |
Countries
United Kingdom
Outcome results
None listed