Photodynamic Therapy (PDT) for Oral Disinfection

PDT With Blue Light and Curcumin for Oral Disinfection

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02152475

Enrollment

Registered

2014-06-02

Start date

2013-05-31

Completion date

2013-11-30

Last updated

2014-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Blue-LED, Curcumin, PDT, Oral disinfection

Brief summary

Photodynamic therapy (PDT) is a technique used for the oral disinfection. In dentistry, PDT for microbial inactivation may reduces both dental plaque and risk of developing caries as well as contributes to treat gingivitis, periodontitis, peri-implantitis and endodontic diseases. The investigators hypothesis was that PDT with blue light and curcumin promotes oral disinfection during 2 hours after treatment.

Detailed description

PDT uses a non-toxic drug that is activated by exposure to light in the presence of oxygen. The excited state this drug transfers energy or electrons to ground state molecular oxygen producing cytotoxic effects on cell. There are productions of reactive oxygen species (ROS) and disrupts several of the cell's functions. This results in bacterial disinfection. In order to perform the PDT on the oral cavity, a device based on blue LED with transparent acrylic diffuser tip and cylindrical shape was developed.

Interventions

DRUGmouthwash with curcumin

Mouthwash with 20 ml of curcumin solution for 5 minutes

DEVICEblue LED illumination

Oral cavity was illuminated with blue light for 5 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* non-users of any antibiotic therapy * those who do not perform any oral hygiene, such as flossing, brushing and antiseptic mouthwash * those who performed 12-hour fasting prior the treatment and measurements

Exclusion criteria

* oral cancer * smoking habits * pregnancy * patients with partial or total dentures * orthodontic brackets users

Design outcomes

Primary

Measure	Time frame	Description
Microbiological analysis by the total number of colony-forming units (CFU).	Two hours	Two saliva samples from each volunteer were collected. The saliva samples underwent serial dilutions and 100-microliters aliquots were plated on brain heart infusion agar plates (in duplicate) and then incubated under microaerophilic conditions. After incubation, the total number of colony-forming units (CFU) was determined.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026