Cataract, Keratitis, Pterygium, Retina Detachment, Vitreous Hemorrhage
Conditions
Brief summary
We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.
Interventions
DRUGSevoflurane
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patient scheduled for ophthalmic surgery under general anesthesia * American Society of Anesthesiologist physical status I or II
Exclusion criteria
* hematologic disorder * severe anemia * liver disease * kidney disease * taking a medication interfering with hemostasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clotting time of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia |
| Clot firmness time of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia |
| Alpha angle of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia |
| Maximum clot firmness of ROTEM | 10 minutes before the induction of anesthesia, 1 h after finishing anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Activated partial thromboplastin time | 10 minutes before the induction of anesthesia |
| Hemoglobin | 10 minutes before the induction of anesthesia |
| Fibrinogen | 10 minutes before the induction of anesthesia |
| Hematocrit | 10 minutes before the induction of anesthesia |
| Platelet count | 10 minutes before the induction of anesthesia |
| International normalized ratio of prothrombin time | 10 minutes before the induction of anesthesia |
Countries
South Korea
Outcome results
None listed