Neurological Movement Disorders
Conditions
Brief summary
The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).
Interventions
None listed
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* control subjects: no neurological movement disorder * patients: neurological movement disorder
Exclusion criteria
patients and control subjects: * presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent * presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes * for the electrical stimulation examination, subjects with metal implants are also excluded * for the TMS and GVS examination, subjects with the following conditions are excluded: metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spinal reflex activity | one day | Spinal reflex activity will be assessed by electrical nerve stimulation |
Countries
Switzerland
Outcome results
None listed