COPD, Exercise, Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test)
Conditions
Keywords
Oxygen therapy, Hypoxemia, COPD, Closed-loop, Automated titration,
Brief summary
The aim of the current study was to evaluate a new system (FreeO2) that automatically titrates oxygen flow to maintain stable SpO2, in patients with moderate or severe chronic obstructive pulmonary disease during exercise. The investigators hypothesized that continuous automatic adjustment of the oxygen flows during exercise would better maintain patients within the oxygenation target, reduce episodes of desaturation and hyperoxia and would improve walking exercise tolerance in comparison with fixed levels of low-flow oxygen and with compressed air breathing.
Interventions
Automated oxygen titration every second to maintain stable SpO2 at a predefined value (94% in the present study)
DRUGCompressed air
compressed air delivered at a fixed flow of 2 L/min
DRUGOxygen constant flow
oxygen delivered at a fixed flow of 2L/min
Sponsors
Fonds de la Recherche en Santé du Québec
Canada Foundation for Innovation
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 40 years * Moderate to severe COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines * Who did not require long-term oxygen therapy were included in the study. * Patients were also selected on the basis of known (end-exercise SpO2 \< 90% on a previous exercise test) or suspected (SpO2 \< 95% at rest) desaturation during exercise
Exclusion criteria
* Episode of exacerbation or hospitalisation within last four weeks * Current medical condition that could influence exercise tolerance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time within predefined SpO2 target | during exercise (Endurance shuttle walking test) | The primary outcome of the study was the percentage of exercise time during which patients were kept within the SpO2 target of 92 to 96% |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Exercise tolerance | duration of ESWT | Endurance shuttle walking test time and distance |
Other
| Measure | Time frame | Description |
|---|---|---|
| Physiological parameters | during ESWT | Physiological parameters continuously recorded by the FreeO2 system (SpO2, end-tidal CO2 \[EtCO2\], respiratory rate, heart rate and oxygen flow when automated oxygen titration was activated), blood gases (before and after ESWT and after recovery) and dyspnea assessment during ESWT with a 10-point Borg scale |
Countries
Canada
Outcome results
None listed