Intensity Modulated Radiotherapy With Chemotherapy, Nasopharyngeal Cancers
Conditions
Brief summary
In the treatment of nasopharyngeal cancers, to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.
Detailed description
The purpose of this study was to determine the feasibility in delivering induction chemotherapy and concomitant chemotherapy with IMRT in the treatment of locally advanced nasopharyngeal cancers and to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.
Interventions
RADIATIONIntensity modulated radiotherapy with chemotherapy
Sponsors
Royal Marsden NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* nasopharyngeal cancers
Exclusion criteria
* Patients \<16 years old or with a previous malignancy other than non-melanomatous skin cancer were excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of ≥G2 xerostomia at 1 year using the subjective component LENTSOMA | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Acute radiation toxicities | 0-3 months |
| Late radiation toxicities | 3-24 months |
| loco-regional disease-free survival (LRDFS), progression-free survival (PFS) and overall survival (OS) | 2 years |
| chemotherapy compliance and toxicities | 0-12 weeks |
Countries
United Kingdom
Outcome results
None listed