Prostate Cancer
Conditions
Brief summary
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response. Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane. To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well. Secondarily, kidney protection effect of propofol over desflurane will be compared.
Interventions
DRUGpropofol
DRUGDesflurane
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia
Exclusion criteria
* chronic renal failure ( estimated glomerular filtration rate \<60 mL/min/1.73m2) * allergy to propofol, nuts * on diuretics, vitamin C or vitamin E within 5 days before surgery * Body mass index \> 30 kg/m2 * older than 70 years * who cannot read the patient consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation | 100 min after pneumoperitoneum, 10 min after decompression |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| kidney function after anesthesia | 1 day after operation | measure creatinine |
Countries
South Korea
Outcome results
None listed