Hypopharyngeal Squamous Cell Cancer, Oropharyngeal Squamous Cell Cancer
Conditions
Keywords
involvement of bilateral parapharyngeal spaces
Brief summary
This study is a phase II trial designed to test the feasibility of delivering IMRT to head and neck cancer patients with tumours arising in the midline (oropharynx and hypopharynx), and to assess possible improvement in reducing the incidence of xerostomia with bilateral superficial lobe parotid sparing IMRT.
Interventions
RADIATIONIntensity modulated radiotherapy
Bilateral superficial lobe parotid sparing intensity modulated radiotherapy
Sponsors
Royal Marsden NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* histologically confirmed locally advanced HNSCC arising from the oropharynx or hypopharynx with high risk of bilateral parapharyngeal space involvement
Exclusion criteria
* Patients \<18 years old or with a previous malignancy other than non-melanomatous skin cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients reporting grade 2 or more xerostomia using subjective measure on the LENTSOMA late toxicity scoring scale one year after treatment. | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Acute radiation toxicity | 0-3 months |
| Late radiation toxicity | 3-24 months |
| Survival outcomes for entire cohort and according to HPV status where available : Local control, Loco regional control, Loco-regional progression-free survival (LRPFS), Disease free survival, Overall survival. | 24 months |
Countries
United Kingdom
Outcome results
None listed