Cardiomyopathy, End Stage Heart Disease, Heart Failure, Myocardial Ischemic Reperfusion Injury
Conditions
Brief summary
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
Interventions
PROCEDURERIPC+RIPostC
Four 5 min cycles of upper limb ischemia and reperfusion by a cuff inflated to 200 mmHg, twice (after anesthesia induction and before surgery started, at 20min after aortic declamping)
PROCEDUREcontrol
a deflated cuff placed on the right upper arm
Sponsors
Chinese Academy of Medical Sciences, Fuwai Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
14 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* scheduled for elective orthotopic heart transplantation surgery
Exclusion criteria
* peripheral vascular disease affecting the upper arms * mechanical circulatory support before surgery * taking the antidiabetic sulphonylurea, glibenclamide * cold ischemic time of donor heart \> 12 hours * repeated heart surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum cardiac troponin I (cTnI) | within 72 hours after aortic declamping |
Secondary
| Measure | Time frame |
|---|---|
| plasma microRNA-133b (miR-133b) | within 72 hours after aortic declamping |
| plasma microRNA-208a (miR-208a) | within 72 hours after aortic declamping |
Countries
China
Outcome results
None listed