Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02148536

Enrollment

Registered

2014-05-28

Start date

2014-06-30

Completion date

2015-09-30

Last updated

2018-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatopulmonary Syndrome

Brief summary

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

Interventions

PROCEDURETransjugular intrahepatic portosystemic shunt

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Presence of cirrhosis * Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age \> 64 years) * Positive contrast-enhanced echocardiography

Exclusion criteria

* Age of less than 18 years * Intrinsic cardiopulmonary disease * Malignancy * Active infection * Pregnancy * Previous shunt therapy * Refusal to participate

Design outcomes

Primary

Measure	Time frame
Alveolar-arterial oxygen gradient (PA-a,O2)	12 Weeks

Secondary

Measure	Time frame
Macroaggregated albumin (MAA) shunt fraction	12 Weeks
Exhaled nitric oxide (eNO)	12 Weeks

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026