Sleep Apnea Syndrome
Conditions
Keywords
sleep apnea syndrome, fiberoptic bronchoscopy, IV sedation
Brief summary
Venous thromboembolism(VTE) is the third most common cardiovascular complication among hospitalized patients, and can even cause death. VTE often occurs in intensive care patients and there had been many efforts to prevent such complication. The American College of Chest Physicians (ACCP) had published evidence-based clinical practice guideline for VTE prophylaxis. This study focuses on how VTE prophylaxis is being performed in both medical and surgical ICUs in a single University hospital, and sees the differences in such prophylactic patterns.
Interventions
DRUGdexmedetomidine infusion rate, 0.5 mcg/kg/hr
continuous infusion of dexmedetomidine at rate of 0.5 mcg/kg/hr
DRUGdexmedetomidine infusion rate, 1.0 mcg/kg/hr
continuous infusion of dexmedetomidine at rate of 1.0 mcg/kg/hr
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. 20-60 years old patients with ASA class I-II 2. Scheduled for drug induced sleep endoscope after diagnosed with sleep apnea syndrome
Exclusion criteria
1. Patients having hearing difficulties, taking any CNS related medication, history of any adverse drug reaction, Glasgow coma scale \< 15 2. Patients with severe cardiopulmonary dysfunction 3. Patients refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Desaturation rate | Baseline from 5 min after remifentanil TCI start, 10 min after dexmedetomidine loading start, every 5 min until surgeon can do endoscopy successfully, to immediately after endoscopy | SpO2 \< 90% (checked by pulse oximetry) |
Countries
South Korea
Outcome results
None listed