Cerebral Anoxia, Cerebral Ischemia, Hypertension, Surgical Complications From General Anesthesia
Conditions
Keywords
hypertension, cerebral oxygen saturation, near-infrared spectroscopy, cognitive function
Brief summary
The purpose of this study is to determine whether there is a significant decrease in cerebral oxygen saturation in hypertensive patients undergoing major abdominal surgery and their correlation with standard monitoring parameters.
Interventions
None listed
Sponsors
Huazhong University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients have hypertension more than 3 year,whether well-controlled or uncontrolled, * scheduled for major abdominal surgery for at least 2 h * under general anesthesia * American Society of Anesthesiologists（ASA）physical status : II \ III * Age \> 30
Exclusion criteria
* pre-existing cerebral pathology for example episodes of cerebral ischemia or stroke; * ASA physical status \>IV * hepatic failure * renal failure * preoperative Mini-Mental State Examination (MMSE) score less than 24 * a history of cardiovascular surgery or craniotomy * cardiac failure * respiratory failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| decreases in cerebral oxygen saturation (rSO2) during the surgery | every 5 minutes throughout the surgery |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in Mini-Mental State Exam (MMSE) perioperative period | Baseline, 4 day after surgery |
Countries
China
Outcome results
None listed