Radial Artery Function Following Trans-radial Cardiac Catheterisation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02147119

Enrollment

Registered

2014-05-26

Start date

2014-03-31

Completion date

2015-12-31

Last updated

2017-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Brief summary

The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.

Interventions

PROCEDURECoronary angiography

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation

Exclusion criteria

* Recent myocardial infarction (\<3 months) * Severe aortic stenosis * Chronic renal failure (eGFR\<30) * Inability to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Change in Flow-mediated dilatation	baseline, 24 hours, one week, four weeks and three months post-angiography	Radial artery flow-mediated dilatation will be assessed at the above stated time points

Secondary

Measure	Time frame	Description
Radial artery injury	Baseline and up to 1 hour Post angiograpy sheath insertion	Optical coherence tomography examination of the radial artery will be made at baseline and following sheath insertion.
Endothelial progenitor cell number an function Endothelial progenitor cell number and function	Baseline and at 24 hours post-angiogram	—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026