Cognitive Impairment, End-Stage Renal Disease
Conditions
Keywords
ESRD, Kidney Failure, Exercise, Cognitive impairment
Brief summary
The purpose of this study is to evaluate the impact of 12 weeks of exercise on cognition in patients with end stage renal disease.
Detailed description
Patients with end stage renal disease have higher cognitive impairment than general population. They also have decreased physical and functional capacity. Exercise has shown to improve cognition in general population. This study will evaluate if exercise improves cognition in dialysis patients. It will also evaluate whether exercise affects performance in daily activities, mood or depression and inflammatory markers in the blood.
Interventions
OTHERAerobic Exercise
Each exercise session will be conducted at the KUMC Exercise and Cardiovascular Health (REACH) Laboratory. Exercise sessions will include a warm-up period, exercise period and a cool down period. Exercise intervention individualized based on health of participant. Subject will be asked to completed two exercise sessions per week for 12 weeks.
PROCEDUREStandard Care Dialysis
12 weeks of standard of care.
Sponsors
University of Kansas Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with ESRD on dialysis * Age greater than 20 years * Have means of transportation to and from the exercise session * Speak English (as the neuropsychological tests will be performed in English)
Exclusion criteria
* Recent myocardial infarction (within 6 weeks), unstable angina, uncontrolled arrhythmias, congestive heart failure (\> NYHA grade II) * History of stroke in the last 2 months * Active respiratory disease * Uncontrolled hypertension * Severe uncontrolled diabetes * Persistent predialysis hyperkalemia * Active decompensated liver disease * Symptomatic peripheral vascular disease * Musculoskeletal abnormalities that will be prohibit their participation in the exercise program * Health conditions needing frequent hospitalizations * Other health conditions causing inability to follow exercise program correctly * Unwillingness to participate in structured exercise program * Current use of antipsychotics or anti-epileptics * Inability to hear, read or write which will limit their ability to perform the cognitive tests
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility | Up to 26 Weeks | Subject compliance with exercise training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | Baseline, within1 week before and within 1 week after exercise intervention | Measured using a standard battery of neuropsychological tests. |
| Markers of inflammation | Baseline, within 1 week before and within 1 week after exercise intervention | Markers of inflammation will be evaluated before and after exercise intervention |
Countries
United States
Outcome results
None listed